Research has shown that PlexR is safe, among other things, because the energy pulses do not penetrate further through the skin than the basal layer of the superficial skin. The advantage of PlexR over techniques such as laser and electrical devices is that the energy pulses are limited to the surface of the skin without penetrating to the deeper layers where it can cause damage.

The energy pulse switches itself off after contact with the skin and, unlike other techniques, is not spread further throughout the body. This makes the treatment very safe and problems such as scars and pigment disturbances will not occur. After the treatment, the healing skin is extra sensitive and it is important to protect well from the sun.